Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline

There is strong evidence that obesity has deleterious effects on cognitive function of older adults. Previous preclinical studies demonstrate that obesity in aging is associated with a heightened state of systemic inflammation, which exacerbates blood–brain barrier disruption, promoting neuroinflamm...

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Dades bibliogràfiques
Publicat a:J Gerontol A Biol Sci Med Sci
Autors principals: Valcarcel-Ares, Marta Noa, Tucsek, Zsuzsanna, Kiss, Tamas, Giles, Cory B, Tarantini, Stefano, Yabluchanskiy, Andriy, Balasubramanian, Priya, Gautam, Tripti, Galvan, Veronica, Ballabh, Praveen, Richardson, Arlan, Freeman, Willard M, Wren, Jonathan D, Deak, Ferenc, Ungvari, Zoltan, Csiszar, Anna
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
The Journal of Gerontology: Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6376091/
https://ncbi.nlm.nih.gov/pubmed/29893815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/gly127
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