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Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

Assembly of microtubule-associated protein tau into filamentous inclusions underlies a range of neurodegenerative diseases. Tau filaments adopt different conformations in Alzheimer’s and Pick’s diseases. Here, we used cryo- and immuno- electron microscopy to characterise filaments that were assemble...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Zhang, Wenjuan, Falcon, Benjamin, Murzin, Alexey G, Fan, Juan, Crowther, R Anthony, Goedert, Michel, Scheres, Sjors HW
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6375701/
https://ncbi.nlm.nih.gov/pubmed/30720432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43584
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