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G protein signaling–biased agonism at the κ-opioid receptor is maintained in striatal neurons
Biased agonists of G protein–coupled receptors may present a means to refine receptor signaling in a way that separates side effects from therapeutic properties. Several studies have shown that agonists that activate the κ-opioid receptor (KOR) in a manner that favors G protein coupling over β-arres...
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| Pubblicato in: | Sci Signal |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6373773/ https://ncbi.nlm.nih.gov/pubmed/30087177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aar4309 |
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