T cell receptor cross-reactivity expanded by dramatic peptide/MHC adaptability

T cell receptor cross-reactivity allows a fixed T cell repertoire to respond to a much larger universe of potential antigens. Recent work has emphasized the importance of peptide structural and chemical homology, as opposed to sequence similarity, in T cell receptor cross-reactivity. Surprisingly th...

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Udgivet i:Nat Chem Biol
Main Authors: Riley, Timothy P., Hellman, Lance M., Gee, Marvin H., Mendoza, Juan L., Alonso, Jesus A., Foley, Kendra C., Nishimura, Michael. I., Vander Kooi, Craig W., Garcia, K. Christopher, Baker, Brian M.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6371774/
https://ncbi.nlm.nih.gov/pubmed/30224695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-018-0130-4
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