How an alloreactive T-cell receptor achieves peptide and MHC specificity

T-cell receptor (TCR) allorecognition is often presumed to be relatively nonspecific, attributable to either a TCR focus on exposed major histocompatibility complex (MHC) polymorphisms or the degenerate recognition of allopeptides. However, paradoxically, alloreactivity can proceed with high peptide...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Wang, Yuan, Singh, Nishant K., Spear, Timothy T., Hellman, Lance M., Piepenbrink, Kurt H., McMahan, Rachel H., Rosen, Hugo R., Vander Kooi, Craig W., Nishimura, Michael I., Baker, Brian M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474831/
https://ncbi.nlm.nih.gov/pubmed/28572406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700459114
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