Wird geladen...
Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro
T cell receptors (TCRs) bind to peptide-major histocompatibility complex (pMHC) with low affinity (K(d) ∼ μM), which is generally assumed to facilitate cross-reactive TCR “scanning” of ligands. To understand the relationship between TCR/pMHC affinity and cross-reactivity, we sought to engineer an ad...
Gespeichert in:
| Veröffentlicht in: | Proc Natl Acad Sci U S A |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2018
|
| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6077720/ https://ncbi.nlm.nih.gov/pubmed/30021852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1802746115 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|