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Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro
T cell receptors (TCRs) bind to peptide-major histocompatibility complex (pMHC) with low affinity (K(d) ∼ μM), which is generally assumed to facilitate cross-reactive TCR “scanning” of ligands. To understand the relationship between TCR/pMHC affinity and cross-reactivity, we sought to engineer an ad...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6077720/ https://ncbi.nlm.nih.gov/pubmed/30021852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1802746115 |
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