Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro

T cell receptors (TCRs) bind to peptide-major histocompatibility complex (pMHC) with low affinity (K(d) ∼ μM), which is generally assumed to facilitate cross-reactive TCR “scanning” of ligands. To understand the relationship between TCR/pMHC affinity and cross-reactivity, we sought to engineer an ad...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Gee, Marvin H., Sibener, Leah V., Birnbaum, Michael E., Jude, Kevin M., Yang, Xinbo, Fernandes, Ricardo A., Mendoza, Juan L., Glassman, Caleb R., Garcia, K. Christopher
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
PNAS Plus
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077720/
https://ncbi.nlm.nih.gov/pubmed/30021852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1802746115
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