Hemi-methylated CpG sites connect Dnmt1-knockdown-induced and Tet1-induced DNA demethylation during somatic cell reprogramming

The relationship between active DNA demethylation induced by overexpressing Tet1 and passive DNA demethylation induced by suppressing Dnmt1 remains unclear. Here, we found that DNMT1 preferentially methylated, but TET1 preferentially demethylated, hemi-methylated CpG sites. These phenomena resulted...

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書誌詳細
出版年:Cell Discov
主要な著者: He, Songwei, Wang, Fuhui, Zhang, Yixin, Chen, Jinlong, Liang, Lining, Li, Yuan, Zhang, Mengdan, Yang, Xiao, Pang, Hongshen, Li, Yingying, Huang, Xiaofen, Qin, Dajiang, Pei, Duanqing, Sun, Hao, Zheng, Hui
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370818/
https://ncbi.nlm.nih.gov/pubmed/30774978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-018-0074-6
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