Hemi-methylated CpG sites connect Dnmt1-knockdown-induced and Tet1-induced DNA demethylation during somatic cell reprogramming

The relationship between active DNA demethylation induced by overexpressing Tet1 and passive DNA demethylation induced by suppressing Dnmt1 remains unclear. Here, we found that DNMT1 preferentially methylated, but TET1 preferentially demethylated, hemi-methylated CpG sites. These phenomena resulted...

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Detalhes bibliográficos
Publicado no:Cell Discov
Main Authors: He, Songwei, Wang, Fuhui, Zhang, Yixin, Chen, Jinlong, Liang, Lining, Li, Yuan, Zhang, Mengdan, Yang, Xiao, Pang, Hongshen, Li, Yingying, Huang, Xiaofen, Qin, Dajiang, Pei, Duanqing, Sun, Hao, Zheng, Hui
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370818/
https://ncbi.nlm.nih.gov/pubmed/30774978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-018-0074-6
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