Hemi-methylated CpG sites connect Dnmt1-knockdown-induced and Tet1-induced DNA demethylation during somatic cell reprogramming

The relationship between active DNA demethylation induced by overexpressing Tet1 and passive DNA demethylation induced by suppressing Dnmt1 remains unclear. Here, we found that DNMT1 preferentially methylated, but TET1 preferentially demethylated, hemi-methylated CpG sites. These phenomena resulted...

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Publicado en:Cell Discov
Autores principales: He, Songwei, Wang, Fuhui, Zhang, Yixin, Chen, Jinlong, Liang, Lining, Li, Yuan, Zhang, Mengdan, Yang, Xiao, Pang, Hongshen, Li, Yingying, Huang, Xiaofen, Qin, Dajiang, Pei, Duanqing, Sun, Hao, Zheng, Hui
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370818/
https://ncbi.nlm.nih.gov/pubmed/30774978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-018-0074-6
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