Passive DNA demethylation preferentially up-regulates pluripotency-related genes and facilitates the generation of induced pluripotent stem cells

A high proliferation rate has been observed to facilitate somatic cell reprogramming, but the pathways that connect proliferation and reprogramming have not been reported. DNA methyltransferase 1 (DNMT1) methylates hemimethylated CpG sites produced during S phase and maintains stable inheritance of...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: He, Songwei, Sun, Hao, Lin, Lilong, Zhang, Yixin, Chen, Jinlong, Liang, Lining, Li, Yuan, Zhang, Mengdan, Yang, Xiao, Wang, Xiaoshan, Wang, Fuhui, Zhu, Feiyan, Chen, Jiekai, Pei, Duanqing, Zheng, Hui
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5682964/
https://ncbi.nlm.nih.gov/pubmed/28924038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.810457
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