Genome-wide CNV analysis in mouse induced pluripotent stem cells reveals dosage effect of pluripotent factors on genome integrity

BACKGROUND: Induced pluripotent stem cells (iPSCs) derived from somatic cells have enormous potential for clinical applications. Notably, it was recently reported that reprogramming from somatic cells to iPSCs can induce genomic copy number variation (CNV), which is one of the major genetic causes o...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Chen, Yulin, Guo, Lin, Chen, Jiekai, Zhao, Xiangjie, Zhou, Weichen, Zhang, Cheng, Wang, Jiucun, Jin, Li, Pei, Duanqing, Zhang, Feng
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912500/
https://ncbi.nlm.nih.gov/pubmed/24472662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-79
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