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Pyrene-Based Quantitative Detection of the 5-Formylcytosine Loci Symmetry in the CpG Duplex Content during TET-dependent Demethylation
5-Methylcytosine (5mC) is mostly symmetrically distributed in CpG islands. Ten-eleven-translocation (TET) proteins are the key enzymes involved in active DNA demethylation through stepwise oxidation of 5mC. However, oxidation pathways of TET enzymes in the symmetrically methylated CpG context are st...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4227401/ https://ncbi.nlm.nih.gov/pubmed/25159856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201406220 |
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