Improving T Cell Receptor On-Target Specificity via Structure-Guided Design

T cell receptors (TCRs) have emerged as a new class of immunological therapeutics. However, though antigen specificity is a hallmark of adaptive immunity, TCRs themselves do not possess the high specificity of monoclonal antibodies. Although a necessary function of T cell biology, the resulting cros...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Ther
Hauptverfasser: Hellman, Lance M., Foley, Kendra C., Singh, Nishant K., Alonso, Jesus A., Riley, Timothy P., Devlin, Jason R., Ayres, Cory M., Keller, Grant L.J., Zhang, Yuting, Vander Kooi, Craig W., Nishimura, Michael I., Baker, Brian M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2019
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6369632/
https://ncbi.nlm.nih.gov/pubmed/30617019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.12.010
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