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Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor

T cell receptors (TCRs) are key to antigen-specific immunity and are increasingly being explored as therapeutics, most visibly in cancer immunotherapy. As TCRs typically possess only low-to-moderate affinity for their peptide/MHC (pMHC) ligands, there is a recognized need to develop affinity-enhance...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Pierce, Brian G., Hellman, Lance M., Hossain, Moushumi, Singh, Nishant K., Vander Kooi, Craig W., Weng, Zhiping, Baker, Brian M.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2014
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923660/
https://ncbi.nlm.nih.gov/pubmed/24550723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003478
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