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Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor
T cell receptors (TCRs) are key to antigen-specific immunity and are increasingly being explored as therapeutics, most visibly in cancer immunotherapy. As TCRs typically possess only low-to-moderate affinity for their peptide/MHC (pMHC) ligands, there is a recognized need to develop affinity-enhance...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3923660/ https://ncbi.nlm.nih.gov/pubmed/24550723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003478 |
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