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High-resolution structure of a Y27W mutant of the Dishevelled2 DIX domain

Dishevelled (Dvl) is a positive regulator of the canonical Wnt pathway that downregulates the phosphorylation of β-catenin and its subsequent degradation. Dvl contains an N-terminal DIX domain, which is involved in its homooligomerization and interactions with regulators of the Wnt pathway. The crys...

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Detalhes bibliográficos
Publicado no:Acta Crystallogr F Struct Biol Commun
Main Authors: Yamanishi, Kumpei, Sin, Yooksil, Terawaki, Shin-ichi, Higuchi, Yoshiki, Shibata, Naoki
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360446/
https://ncbi.nlm.nih.gov/pubmed/30713163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X18018290
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