Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization

Dishevelled relays Wnt signals from the plasma membrane to different cytoplasmic effectors. Its signalling activity depends on its DIX domain, which undergoes head-to-tail polymerization to assemble signalosomes. The DIX domain is ubiquitinated in vivo at multiple lysines, which can be antagonized b...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Madrzak, Julia, Fiedler, Marc, Johnson, Christopher M., Ewan, Richard, Knebel, Axel, Bienz, Mariann, Chin, Jason W.
Format: Artigo
Language:Inglês
Published: Nature Pub. Group 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423210/
https://ncbi.nlm.nih.gov/pubmed/25907794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7718
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