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The structural and functional determinants of the Axin and Dishevelled DIX domains

BACKGROUND: The dishevelled and axin genes encode multi-domain proteins that play key roles in WNT signalling. Dishevelled prevents β-catenin degradation by interfering with the interaction of β-catenin with the degradation-mediating Axin-APC-GSK3β complex. This interference leads to an accumulation...

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Autors principals: Ehebauer, Matthias T, Arias, Alfonso Martinez
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780430/
https://ncbi.nlm.nih.gov/pubmed/19909509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-9-70
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