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The structural and functional determinants of the Axin and Dishevelled DIX domains
BACKGROUND: The dishevelled and axin genes encode multi-domain proteins that play key roles in WNT signalling. Dishevelled prevents β-catenin degradation by interfering with the interaction of β-catenin with the degradation-mediating Axin-APC-GSK3β complex. This interference leads to an accumulation...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2780430/ https://ncbi.nlm.nih.gov/pubmed/19909509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-9-70 |
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