Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor

Although chemotherapy is a conventional cancer treatment, it may induce a protumorigenic microenvironment by triggering the release of proinflammatory mediators. In this study, we demonstrate that ovarian tumor cell debris generated by first-line platinum- and taxane-based chemotherapy accelerates t...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Gartung, Allison, Yang, Jun, Sukhatme, Vikas P., Bielenberg, Diane R., Fernandes, Djanira, Chang, Jaimie, Schmidt, Birgitta A., Hwang, Sung Hee, Zurakowski, David, Huang, Sui, Kieran, Mark W., Hammock, Bruce D., Panigrahy, Dipak
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358686/
https://ncbi.nlm.nih.gov/pubmed/30647111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803999116
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