A DUAL COX-2/sEH INHIBITOR IMPROVES THE METABOLIC PROFILE AND REDUCES KIDNEY INJURY IN ZUCKER DIABETIC FATTY RAT

Cyclooxygenase (COX) and soluble epoxide hydrolase (sEH) inhibitors have therapeutic potential. The present study investigated efficacy of a novel dual acting COX-2/sEH inhibitor, PTUPB in type 2 diabetic Zucker Diabetic Fatty (ZDF) rats. Male ZDF rats were treated with vehicle or PTUPB (10 mg/kg/d,...

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Vydáno v:Prostaglandins Other Lipid Mediat
Hlavní autoři: Khan, Md. Abdul Hye, Hwang, Sung Hee, Sharma, Amit, Corbett, John A., Hammock, Bruce D., Imig, John D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035206/
https://ncbi.nlm.nih.gov/pubmed/27432695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.prostaglandins.2016.07.003
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