A DUAL COX-2/sEH INHIBITOR IMPROVES THE METABOLIC PROFILE AND REDUCES KIDNEY INJURY IN ZUCKER DIABETIC FATTY RAT

Cyclooxygenase (COX) and soluble epoxide hydrolase (sEH) inhibitors have therapeutic potential. The present study investigated efficacy of a novel dual acting COX-2/sEH inhibitor, PTUPB in type 2 diabetic Zucker Diabetic Fatty (ZDF) rats. Male ZDF rats were treated with vehicle or PTUPB (10 mg/kg/d,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Prostaglandins Other Lipid Mediat
Prif Awduron: Khan, Md. Abdul Hye, Hwang, Sung Hee, Sharma, Amit, Corbett, John A., Hammock, Bruce D., Imig, John D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035206/
https://ncbi.nlm.nih.gov/pubmed/27432695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.prostaglandins.2016.07.003
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