COX-2/sEH dual inhibitor PTUPB suppresses glioblastoma growth by targeting epidermal growth factor receptor and hyaluronan mediated motility receptor

AIMS: Cyclooxygenase-2 (COX-2)/soluble epoxide hydrolase (sEH) dual inhibitor, PTUPB, has been demonstrated to inhibit angiogenesis, primary tumor growth and metastasis. The aim of this study is to investigate the effects of PTUPB on glioblastoma cells and xenograft model. RESULTS: We show here that...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Li, Junyang, Zhou, Yali, Wang, Handong, Gao, Yongyue, Li, Liwen, Hwang, Sung Hee, Ji, Xiangjun, Hammock, Bruce D
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675638/
https://ncbi.nlm.nih.gov/pubmed/29152086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20928
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