COX-2/sEH dual inhibitor PTUPB suppresses glioblastoma growth by targeting epidermal growth factor receptor and hyaluronan mediated motility receptor

AIMS: Cyclooxygenase-2 (COX-2)/soluble epoxide hydrolase (sEH) dual inhibitor, PTUPB, has been demonstrated to inhibit angiogenesis, primary tumor growth and metastasis. The aim of this study is to investigate the effects of PTUPB on glioblastoma cells and xenograft model. RESULTS: We show here that...

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Publicado en:Oncotarget
Autores principales: Li, Junyang, Zhou, Yali, Wang, Handong, Gao, Yongyue, Li, Liwen, Hwang, Sung Hee, Ji, Xiangjun, Hammock, Bruce D
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675638/
https://ncbi.nlm.nih.gov/pubmed/29152086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20928
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