COX-2/sEH Dual Inhibitor PTUPB Potentiates the Anti-tumor Efficacy of Cisplatin

Cisplatin-based therapy is highly toxic, but moderately effective in most cancers. Concurrent inhibition of cyclooxygenase-2 (COX-2) and soluble epoxide hydrolase (sEH) results in anti-tumor activity, and has organ protective effects. The goal of this study was to determine the anti-tumor activity o...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Wang, Fuli, Zhang, Hongyong, Ma, Ai-Hong, Yu, Weimin, Zimmermann, Maike, Yang, Jun, Hwang, Sung Hee, Zhu, Daniel, Lin, Tzu-yin, Malfatti, Michael, Turteltaub, Kenneth W, Henderson, Paul T., Airhart, Susan, Hammock, Bruce D., Yuan, Jianlin, de Vere White, Ralph W., Pan, Chong-Xian
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824635/
https://ncbi.nlm.nih.gov/pubmed/29284644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0818
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