A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation

Rationale: Dysregulation of arachidonic acid (ARA) metabolism results in inflammation; however, its role in acute lung injury (ALI) remains elusive. In this study, we addressed the role of dysregulated ARA metabolism in cytochromes P450 (CYPs) /cyclooxygenase-2 (COX-2) pathways in the pathogenesis o...

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Podrobná bibliografie
Vydáno v:Theranostics
Hlavní autoři: Yang, Hui-Hui, Duan, Jia-Xi, Liu, Shao-Kun, Xiong, Jian-Bing, Guan, Xin-Xin, Zhong, Wen-Jing, Sun, Chen-Chen, Zhang, Chen-Yu, Luo, Xiao-Qin, Zhang, Yan-Feng, Chen, Ping, Hammock, Bruce D., Hwang, Sung Hee, Jiang, Jian-Xin, Zhou, Yong, Guan, Cha-Xiang
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2020
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7163435/
https://ncbi.nlm.nih.gov/pubmed/32308747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.43108
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