Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice

OBJECTIVE: Life-threatening hypoglycemia is a major limiting factor in the management of diabetes. While it is known that counterregulatory responses to hypoglycemia are impaired in diabetes, molecular mechanisms underlying the reduced responses remain unclear. Given the established roles of the hyp...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Metab
Hauptverfasser: Tooke, Benjamin P., Yu, Hui, Adams, Jessica M., Jones, Graham L., Sutton-Kennedy, Talisha, Mundada, Lakshmi, Qi, Nathan R., Low, Malcolm J., Chhabra, Kavaljit H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358536/
https://ncbi.nlm.nih.gov/pubmed/30503832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.11.004
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