Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice

OBJECTIVE: Life-threatening hypoglycemia is a major limiting factor in the management of diabetes. While it is known that counterregulatory responses to hypoglycemia are impaired in diabetes, molecular mechanisms underlying the reduced responses remain unclear. Given the established roles of the hyp...

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Bibliographic Details
Published in:Mol Metab
Main Authors: Tooke, Benjamin P., Yu, Hui, Adams, Jessica M., Jones, Graham L., Sutton-Kennedy, Talisha, Mundada, Lakshmi, Qi, Nathan R., Low, Malcolm J., Chhabra, Kavaljit H.
Format: Artigo
Language:Inglês
Published: Elsevier 2018
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358536/
https://ncbi.nlm.nih.gov/pubmed/30503832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.11.004
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