Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity

OBJECTIVE: A major challenge for obesity treatment is the maintenance of reduced body weight. Diet-induced obese mice are resistant to achieving normoweight once the obesogenic conditions are reversed, in part because lowered circulating leptin leads to a reduction in metabolic rate and a rebound of...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Chhabra, Kavaljit H., Adams, Jessica M., Jones, Graham L., Yamashita, Miho, Schlapschy, Martin, Skerra, Arne, Rubinstein, Marcelo, Low, Malcolm J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034612/
https://ncbi.nlm.nih.gov/pubmed/27689000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2016.07.012
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