Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria

Hypothalamic proopiomelanocortin (POMC) is essential for the physiological regulation of energy balance; however, its role in glucose homeostasis remains less clear. We show that hypothalamic arcuate nucleus (Arc)POMC-deficient mice, which develop severe obesity and insulin resistance, unexpectedly...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Chhabra, Kavaljit H., Adams, Jessica M., Fagel, Brian, Lam, Daniel D., Qi, Nathan, Rubinstein, Marcelo, Low, Malcolm J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2016
Assuntos:
Obesity Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764146/
https://ncbi.nlm.nih.gov/pubmed/26467632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-0804
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