Reduced renal sympathetic nerve activity contributes to elevated glycosuria and improved glucose tolerance in hypothalamus-specific Pomc knockout mice

OBJECTIVE: Hypothalamic arcuate nucleus-specific pro-opiomelanocortin deficient (ArcPomc(−/−)) mice exhibit improved glucose tolerance despite massive obesity and insulin resistance. We demonstrated previously that their improved glucose tolerance is due to elevated glycosuria. However, the underlyi...

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Bibliografski detalji
Izdano u:Mol Metab
Glavni autori: Chhabra, Kavaljit H., Morgan, Donald A., Tooke, Benjamin P., Adams, Jessica M., Rahmouni, Kamal, Low, Malcolm J.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2017
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641634/
https://ncbi.nlm.nih.gov/pubmed/29031726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.07.005
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