Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem

Both natural influenza infection and current seasonal influenza vaccines primarily induce neutralizing antibody responses against highly diverse epitopes within the “head” of the viral hemagglutinin (HA) protein. There is increasing interest in redirecting immunity toward the more conserved HA stem...

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Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Tan, Hyon-Xhi, Jegaskanda, Sinthujan, Juno, Jennifer A., Esterbauer, Robyn, Wong, Julius, Kelly, Hannah G., Liu, Yi, Tilmanis, Danielle, Hurt, Aeron C., Yewdell, Jonathan W., Kent, Stephen J., Wheatley, Adam K.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355240/
https://ncbi.nlm.nih.gov/pubmed/30521496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123366
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