Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem

Both natural influenza infection and current seasonal influenza vaccines primarily induce neutralizing antibody responses against highly diverse epitopes within the “head” of the viral hemagglutinin (HA) protein. There is increasing interest in redirecting immunity toward the more conserved HA stem...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Tan, Hyon-Xhi, Jegaskanda, Sinthujan, Juno, Jennifer A., Esterbauer, Robyn, Wong, Julius, Kelly, Hannah G., Liu, Yi, Tilmanis, Danielle, Hurt, Aeron C., Yewdell, Jonathan W., Kent, Stephen J., Wheatley, Adam K.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355240/
https://ncbi.nlm.nih.gov/pubmed/30521496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123366
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares