Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem

Both natural influenza infection and current seasonal influenza vaccines primarily induce neutralizing antibody responses against highly diverse epitopes within the “head” of the viral hemagglutinin (HA) protein. There is increasing interest in redirecting immunity toward the more conserved HA stem...

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Udgivet i:J Clin Invest
Main Authors: Tan, Hyon-Xhi, Jegaskanda, Sinthujan, Juno, Jennifer A., Esterbauer, Robyn, Wong, Julius, Kelly, Hannah G., Liu, Yi, Tilmanis, Danielle, Hurt, Aeron C., Yewdell, Jonathan W., Kent, Stephen J., Wheatley, Adam K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355240/
https://ncbi.nlm.nih.gov/pubmed/30521496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123366
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