Humanised effector-null FcγRIIA antibody inhibits immune complex-mediated proinflammatory responses

OBJECTIVE: Immune complexes (ICs) play a critical role in the pathology of autoimmune diseases. The aim of this study was to generate and characterise a first-in-class anti-FcγRIIA antibody (Ab) VIB9600 (previously known as MEDI9600) that blocks IgG immune complex-mediated cellular activation for cl...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Ann Rheum Dis
Κύριοι συγγραφείς: Chen, Bo, Vousden, Katherine A, Naiman, Brian, Turman, Sean, Sun, Hong, Wang, Shu, Vinall, Lisa M K, Kemp, Benjamin P, Kasturiangan, Srinath, Rees, D Gareth, Grant, Ethan, Hinrichs, Mary Jane, Eck, Steven, DiGiandomenico, Antonio, Jack Borrok, M, Ly, Neang, Xiong, Ximing, Gonzalez, Carlos, Morehouse, Christopher, Wang, Yue, Zhou, Yebin, Cann, Jennifer, Zhao, Weiguang, Koelkebeck, Holly, Okubo, Koshu, Mayadas, Tanya N, Howe, David, Griffiths, Janet, Kolbeck, Roland, Herbst, Ronald, Sims, Gary P
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: BMJ Publishing Group 2019
Θέματα:
Connective Tissue Diseases
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6352406/
https://ncbi.nlm.nih.gov/pubmed/30459279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2018-213523
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