Humanised effector-null FcγRIIA antibody inhibits immune complex-mediated proinflammatory responses

OBJECTIVE: Immune complexes (ICs) play a critical role in the pathology of autoimmune diseases. The aim of this study was to generate and characterise a first-in-class anti-FcγRIIA antibody (Ab) VIB9600 (previously known as MEDI9600) that blocks IgG immune complex-mediated cellular activation for cl...

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書誌詳細
出版年:Ann Rheum Dis
主要な著者: Chen, Bo, Vousden, Katherine A, Naiman, Brian, Turman, Sean, Sun, Hong, Wang, Shu, Vinall, Lisa M K, Kemp, Benjamin P, Kasturiangan, Srinath, Rees, D Gareth, Grant, Ethan, Hinrichs, Mary Jane, Eck, Steven, DiGiandomenico, Antonio, Jack Borrok, M, Ly, Neang, Xiong, Ximing, Gonzalez, Carlos, Morehouse, Christopher, Wang, Yue, Zhou, Yebin, Cann, Jennifer, Zhao, Weiguang, Koelkebeck, Holly, Okubo, Koshu, Mayadas, Tanya N, Howe, David, Griffiths, Janet, Kolbeck, Roland, Herbst, Ronald, Sims, Gary P
フォーマット: Artigo
言語:Inglês
出版事項: BMJ Publishing Group 2019
主題:
Connective Tissue Diseases
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6352406/
https://ncbi.nlm.nih.gov/pubmed/30459279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2018-213523
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