Humanised effector-null FcγRIIA antibody inhibits immune complex-mediated proinflammatory responses

OBJECTIVE: Immune complexes (ICs) play a critical role in the pathology of autoimmune diseases. The aim of this study was to generate and characterise a first-in-class anti-FcγRIIA antibody (Ab) VIB9600 (previously known as MEDI9600) that blocks IgG immune complex-mediated cellular activation for cl...

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Bibliografiset tiedot
Julkaisussa:Ann Rheum Dis
Päätekijät: Chen, Bo, Vousden, Katherine A, Naiman, Brian, Turman, Sean, Sun, Hong, Wang, Shu, Vinall, Lisa M K, Kemp, Benjamin P, Kasturiangan, Srinath, Rees, D Gareth, Grant, Ethan, Hinrichs, Mary Jane, Eck, Steven, DiGiandomenico, Antonio, Jack Borrok, M, Ly, Neang, Xiong, Ximing, Gonzalez, Carlos, Morehouse, Christopher, Wang, Yue, Zhou, Yebin, Cann, Jennifer, Zhao, Weiguang, Koelkebeck, Holly, Okubo, Koshu, Mayadas, Tanya N, Howe, David, Griffiths, Janet, Kolbeck, Roland, Herbst, Ronald, Sims, Gary P
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BMJ Publishing Group 2019
Aiheet:
Connective Tissue Diseases
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6352406/
https://ncbi.nlm.nih.gov/pubmed/30459279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2018-213523
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