Humanised effector-null FcγRIIA antibody inhibits immune complex-mediated proinflammatory responses

OBJECTIVE: Immune complexes (ICs) play a critical role in the pathology of autoimmune diseases. The aim of this study was to generate and characterise a first-in-class anti-FcγRIIA antibody (Ab) VIB9600 (previously known as MEDI9600) that blocks IgG immune complex-mediated cellular activation for cl...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Ann Rheum Dis
Prif Awduron: Chen, Bo, Vousden, Katherine A, Naiman, Brian, Turman, Sean, Sun, Hong, Wang, Shu, Vinall, Lisa M K, Kemp, Benjamin P, Kasturiangan, Srinath, Rees, D Gareth, Grant, Ethan, Hinrichs, Mary Jane, Eck, Steven, DiGiandomenico, Antonio, Jack Borrok, M, Ly, Neang, Xiong, Ximing, Gonzalez, Carlos, Morehouse, Christopher, Wang, Yue, Zhou, Yebin, Cann, Jennifer, Zhao, Weiguang, Koelkebeck, Holly, Okubo, Koshu, Mayadas, Tanya N, Howe, David, Griffiths, Janet, Kolbeck, Roland, Herbst, Ronald, Sims, Gary P
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMJ Publishing Group 2019
Pynciau:
Connective Tissue Diseases
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6352406/
https://ncbi.nlm.nih.gov/pubmed/30459279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2018-213523
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg