Rapamycin improves healthspan but not inflammaging in nfκb1 (−/−) mice

Increased activation of the major pro‐inflammatory NF‐κB pathway leads to numerous age‐related diseases, including chronic liver disease (CLD). Rapamycin, an inhibitor of mTOR, extends lifespan and healthspan, potentially via suppression of inflammaging, a process which is partially dependent on NF‐...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Correia‐Melo, Clara, Birch, Jodie, Fielder, Edward, Rahmatika, Dina, Taylor, Jennifer, Chapman, James, Lagnado, Anthony, Carroll, Bernadette M., Miwa, Satomi, Richardson, Gavin, Jurk, Diana, Oakley, Fiona, Mann, Jelena, Mann, Derek A., Korolchuk, Viktor I., Passos, João F.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351839/
https://ncbi.nlm.nih.gov/pubmed/30468013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12882
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