Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in rodents and humans. Nevertheless, important questions remain regarding the optimal dose, duration, and mechanisms of action in the context of healthy aging. Here we show that 3 months of rapamycin tre...

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Veröffentlicht in:eLife
Hauptverfasser: Bitto, Alessandro, Ito, Takashi K, Pineda, Victor V, LeTexier, Nicolas J, Huang, Heather Z, Sutlief, Elissa, Tung, Herman, Vizzini, Nicholas, Chen, Belle, Smith, Kaleb, Meza, Daniel, Yajima, Masanao, Beyer, Richard P, Kerr, Kathleen F, Davis, Daniel J, Gillespie, Catherine H, Snyder, Jessica M, Treuting, Piper M, Kaeberlein, Matt
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2016
Schlagworte:
Cancer Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996648/
https://ncbi.nlm.nih.gov/pubmed/27549339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16351
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