Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in rodents and humans. Nevertheless, important questions remain regarding the optimal dose, duration, and mechanisms of action in the context of healthy aging. Here we show that 3 months of rapamycin tre...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Bitto, Alessandro, Ito, Takashi K, Pineda, Victor V, LeTexier, Nicolas J, Huang, Heather Z, Sutlief, Elissa, Tung, Herman, Vizzini, Nicholas, Chen, Belle, Smith, Kaleb, Meza, Daniel, Yajima, Masanao, Beyer, Richard P, Kerr, Kathleen F, Davis, Daniel J, Gillespie, Catherine H, Snyder, Jessica M, Treuting, Piper M, Kaeberlein, Matt
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2016
Konular:
Cancer Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996648/
https://ncbi.nlm.nih.gov/pubmed/27549339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16351
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