Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity

CRISPR (clustered regularly interspaced short palindromic repeat) endonucleases are at the forefront of biotechnology, synthetic biology and gene editing. Methods for controlling enzyme properties promise to improve existing applications and enable new technologies. CRISPR enzymes rely on RNA cofact...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: O’Reilly, Daniel, Kartje, Zachary J, Ageely, Eman A, Malek-Adamian, Elise, Habibian, Maryam, Schofield, Annabelle, Barkau, Christopher L, Rohilla, Kushal J, DeRossett, Lauren B, Weigle, Austin T, Damha, Masad J, Gagnon, Keith T
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Chemical Biology and Nucleic Acid Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344873/
https://ncbi.nlm.nih.gov/pubmed/30517736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1214
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