Effect of 2′-5′/3′-5′ phosphodiester linkage heterogeneity on RNA interference

We report on the synthesis of siRNAs containing both 2′-5′- and 3′-5′-internucleotide linkages and their effects on siRNA structure, function, and interaction with RNAi proteins. Screening of these siRNAs against their corresponding mRNA targets showed that 2′-5′ linkages were well tolerated in the...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Habibian, Maryam, Harikrishna, S, Fakhoury, Johans, Barton, Maria, Ageely, Eman A, Cencic, Regina, Fakih, Hassan H, Katolik, Adam, Takahashi, Mayumi, Rossi, John, Pelletier, Jerry, Gagnon, Keith T, Pradeepkumar, P I, Damha, Masad J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229817/
https://ncbi.nlm.nih.gov/pubmed/32282904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa222
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