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Effect of 2′-5′/3′-5′ phosphodiester linkage heterogeneity on RNA interference
We report on the synthesis of siRNAs containing both 2′-5′- and 3′-5′-internucleotide linkages and their effects on siRNA structure, function, and interaction with RNAi proteins. Screening of these siRNAs against their corresponding mRNA targets showed that 2′-5′ linkages were well tolerated in the...
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| Izdano u: | Nucleic Acids Res |
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| Glavni autori: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7229817/ https://ncbi.nlm.nih.gov/pubmed/32282904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa222 |
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