Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity

CRISPR (clustered regularly interspaced short palindromic repeat) endonucleases are at the forefront of biotechnology, synthetic biology and gene editing. Methods for controlling enzyme properties promise to improve existing applications and enable new technologies. CRISPR enzymes rely on RNA cofact...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: O’Reilly, Daniel, Kartje, Zachary J, Ageely, Eman A, Malek-Adamian, Elise, Habibian, Maryam, Schofield, Annabelle, Barkau, Christopher L, Rohilla, Kushal J, DeRossett, Lauren B, Weigle, Austin T, Damha, Masad J, Gagnon, Keith T
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344873/
https://ncbi.nlm.nih.gov/pubmed/30517736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1214
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