Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity

CRISPR (clustered regularly interspaced short palindromic repeat) endonucleases are at the forefront of biotechnology, synthetic biology and gene editing. Methods for controlling enzyme properties promise to improve existing applications and enable new technologies. CRISPR enzymes rely on RNA cofact...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: O’Reilly, Daniel, Kartje, Zachary J, Ageely, Eman A, Malek-Adamian, Elise, Habibian, Maryam, Schofield, Annabelle, Barkau, Christopher L, Rohilla, Kushal J, DeRossett, Lauren B, Weigle, Austin T, Damha, Masad J, Gagnon, Keith T
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Chemical Biology and Nucleic Acid Chemistry
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344873/
https://ncbi.nlm.nih.gov/pubmed/30517736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1214
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires