Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity

CRISPR (clustered regularly interspaced short palindromic repeat) endonucleases are at the forefront of biotechnology, synthetic biology and gene editing. Methods for controlling enzyme properties promise to improve existing applications and enable new technologies. CRISPR enzymes rely on RNA cofact...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: O’Reilly, Daniel, Kartje, Zachary J, Ageely, Eman A, Malek-Adamian, Elise, Habibian, Maryam, Schofield, Annabelle, Barkau, Christopher L, Rohilla, Kushal J, DeRossett, Lauren B, Weigle, Austin T, Damha, Masad J, Gagnon, Keith T
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
Soggetti:
Chemical Biology and Nucleic Acid Chemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344873/
https://ncbi.nlm.nih.gov/pubmed/30517736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1214
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