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Loss of two Akt isoforms in hematopoietic cells diminished monocyte and macrophage survival and reduces atherosclerosis in Ldl-receptor null mice
OBJECTIVE: Macrophages express three Akt isoforms, Akt1, Akt2 and Akt3, which display isoform-specific functions but may be redundant in terms of Akt survival signaling. We hypothesize that loss of two Akt isoforms in macrophages will suppress their ability to survive and modulate the development of...
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| Veröffentlicht in: | Arterioscler Thromb Vasc Biol |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6344270/ https://ncbi.nlm.nih.gov/pubmed/30567482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.312206 |
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