Loss of Rictor in Monocyte/Macrophages Suppresses Their Proliferation and Viability Reducing Atherosclerosis in LDLR Null Mice

BACKGROUND: Rictor is an essential component of mammalian target of rapamycin (mTOR) complex 2 (mTORC2), a conserved serine/threonine kinase that may play a role in cell proliferation, survival and innate or adaptive immune responses. Genetic loss of Rictor inactivates mTORC2, which directly activat...

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Bibliografiska uppgifter
I publikationen:Front Immunol
Huvudupphovsmän: Babaev, Vladimir R., Huang, Jiansheng, Ding, Lei, Zhang, Youmin, May, James M., Linton, MacRae F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2018
Ämnen:
Immunology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816794/
https://ncbi.nlm.nih.gov/pubmed/29487597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00215
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