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Jnk1 deficiency in hematopoietic cells suppresses macrophage apoptosis and increases atherosclerosis in LDL-receptor null mice
OBJECTIVE: The c-Jun NH(2)-terminal kinases (JNK) are regulated by a wide variety of cellular stresses and have been implicated in apoptotic signaling. Macrophages express two JNK isoforms, JNK1 and JNK2, which may have different effects on cell survival and atherosclerosis. APPROACH AND RESULTS: To...
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| Publicat a: | Arterioscler Thromb Vasc Biol |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4882236/ https://ncbi.nlm.nih.gov/pubmed/27102962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.307580 |
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