Macrophage Mal1 deficiency suppresses atherosclerosis in LDL-receptor null mice by activating PPARγ-regulated genes

OBJECTIVE: The adipocyte/macrophage fatty acid-binding proteins, aP2 (FABP4) and Mal1 (FABP5), are intracellular lipid chaperones that modulate systemic glucose metabolism, insulin sensitivity and atherosclerosis. Combined deficiency of aP2 and Mal1 has been shown to reduce the development of athero...

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Detalhes bibliográficos
Main Authors: Babaev, Vladimir R., Runner, Robert P., Fan, Daping, Ding, Lei, Zhang, Youmin, Tao, Huan, Erbay, Ebru, Görgün, Cem Z., Fazio, Sergio, Hotamisligil, Gökhan S., Linton, MacRae F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135083/
https://ncbi.nlm.nih.gov/pubmed/21474828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.225839
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