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Differential effector engagement by oncogenic KRAS

KRAS can bind numerous effector proteins, which activate different downstream signaling events. The best known are RAF, PI-3’ kinase and RalGDS families, but many additional direct and indirect effectors have been reported. We have assessed how these effectors contribute to several major phenotypes...

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Vydáno v:Cell Rep
Hlavní autoři: Yuan, Tina L., Amzallag, Arnaud, Bagni, Rachel, Yi, Ming, Afghani, Shervin, Burgan, William, Fer, Nicole, Garvey, Leslie, Powell, Katie, Smith, Brian, Waters, Andrew M., Drubin, David, Thomson, Ty, Liao, Rosy, Greninger, Patricia, Stein, Giovanna T., Murchie, Ellen, Cortez, Eliane, Egan, Regina K., Procter, Lauren, Bess, Matthew, Cheng, Kwong Tai, Lee, Chih-Shia, Lee, Liam Changwoo, Fellmann, Christof, Stephens, Robert, Luo, Ji, Lowe, Scott, Benes, Cyril H., McCormick, Frank
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343826/
https://ncbi.nlm.nih.gov/pubmed/29444439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.051
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