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Accurate Prediction of Amide Exchange in the Fast Limit Reveals Thrombin Allostery

Amide hydrogen/deuterium exchange mass spectrometry (HDXMS) of proteins has become extremely popular for identifying ligand-binding sites, protein-protein interactions, intrinsic disorder, and allosteric changes upon protein modification. Such phenomena are revealed when amide exchange is measured i...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Markwick, Phineus R.L., Peacock, Riley B., Komives, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342732/
https://ncbi.nlm.nih.gov/pubmed/30558884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.11.023
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