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Understanding and overcoming trade-offs between antibody affinity, specificity, stability and solubility
The widespread use of monoclonal antibodies for therapeutic applications has led to intense interest in optimizing several of their natural properties (affinity, specificity, stability, solubility and effector functions) as well as introducing non-natural activities (bispecificity and cytotoxicity m...
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| Опубликовано в: : | Biochem Eng J |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6338232/ https://ncbi.nlm.nih.gov/pubmed/30666176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bej.2018.06.003 |
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