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Understanding and overcoming trade-offs between antibody affinity, specificity, stability and solubility

The widespread use of monoclonal antibodies for therapeutic applications has led to intense interest in optimizing several of their natural properties (affinity, specificity, stability, solubility and effector functions) as well as introducing non-natural activities (bispecificity and cytotoxicity m...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biochem Eng J
Main Authors: Rabia, Lilia A., Desai, Alec A., Jhajj, Harkamal S., Tessier, Peter M.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338232/
https://ncbi.nlm.nih.gov/pubmed/30666176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bej.2018.06.003
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