Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy

The E3 ubiquitin ligase Parkin is a key effector of the removal of damaged mitochondria by mitophagy. Parkin determines cell fate in response to mitochondrial damage, with its loss promoting early onset Parkinson's disease and potentially also cancer progression. Controlling a cell's apopt...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Bernardini, Jonathan P, Brouwer, Jason M, Tan, Iris KL, Sandow, Jarrod J, Huang, Shuai, Stafford, Che A, Bankovacki, Aleksandra, Riffkin, Christopher D, Wardak, Ahmad Z, Czabotar, Peter E, Lazarou, Michael, Dewson, Grant
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331729/
https://ncbi.nlm.nih.gov/pubmed/30573668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899916
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